sigma receptors การใช้

• Unlike its enantiomer, BD1031, BD1018 acts as a sigma receptor antagonist.
• Sigma receptor ligands can act as agonists or antagonists, generating different cellular responses.
• Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist.
• Methamphetamine binds to and activates both sigma receptor subtypes, ? 2, in the brain.
• Some studies have shown that certain sigma receptor inhibitors increase cancer cells'susceptibility to chemotherapy.
• Actions at 5-HT 7, and sigma receptors have also been shown for some azapirones.
• Neuroactive steroids bind to and modulate the activity of several ion channels including the NMDA, and sigma receptors.
• Sigma receptor activation by methamphetamine appears facilitate its central nervous system stimulant effects and promote neurotoxicity within the brain.
• Consistent with other reported sigma receptor agonists, BD1031 increases the behavioural toxicity of cocaine in Swiss Webster mice.
• Consistent with other reported sigma receptor antagonists, BD1018 deccreases the behavioural toxicity of cocaine in Swiss Webster mice.
• Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.
• Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1067 significantly attenuates the behavioral toxicity of cocaine.
• MDMA is a ligand at both sigma receptor subtypes, though its efficacies at the receptors have not yet been elucidated.
• Its actions at the sigma receptor may afford it a unique advantage among antidepressants in treating the cognitive symptoms of schizophrenia.
• Sigma receptor ligands have been conjugated to nanoparticles and peptides to deliver cancer treatment to tumor cells without targeting other tissues.
• "' Rimcazole "'is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor.
• Consistent with other reported sigma receptor agonists, pretreating Swiss Webster mice with BD1052 significantly increases the behavioral toxicity of cocaine.
• W-18 was found to obtain weak activity at both sigma receptors and the translocator protein ( peripheral benzodiazepine receptor ).
• Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with LR132 significantly decreases the convulsivity and lethality of cocaine.
• Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.